Literatur & Quellen

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• Gastroenterologie für die Praxis, Prof. asoc. inv. Dr .med Hartmut Köppen, 1. Auflage, 2010 Georg Thieme Verlag KG, ISBN-Nr. 978-3-13-146761-4

• Mechanisms of reflux perception in gastroesophageal reflux disease, Bredenoord AJ, 2012 Jan; 107(1):8-15

• Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors,
  Sifrim D, Zerbib F, 2012 Jun 16

• Why Stomach Acid is good for you (Ein Lob der Magensäure, Natürliche Linderung von Sodbrennen, Reflux und Verdauungsbeschwerden), Jonathan V. Wright, M.D. & Lane Lenard, Ph. D., MOBIWELL Verlag, Deutsch Erstausgabe 2016, ISBN: 978-3-944887-29-6

• Global, regional and national burdens of gastroesophageal reflux disease from 1990 to 2021 and projections to 2050: a finding from the global burden of disease study 2021, Chen et al. BMC Public Health (2025) 25:3943

• The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn, 
  Division of Gastroenterology, Weill Cornell Medical Center, New York, NY, USA; 2Division of Gastroenterology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA, 2019 Aug; 11 (Suppl 12): S1594–S160

• S2k-Leitlinie "Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis" der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), AWMF-Register-Nr. 021-013.

• Vakil N, van Zanten SV, Kahrilas P, et al. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. American Journal of Gastroenterology. 2006;101(8):1900–1920. DOI: 10.1111/j.1572-0241.2006.00630.x

• Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. American Journal of Gastroenterology. 2022;117(1):27–56. DOI: 10.14309/ajg.0000000000001538

• Dietary Intake in Relation to the Risk of Reflux Disease: A Systematic Review; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd 8916188635, Iran, Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Iran, Prev. Nutr. Food Sci. 2021;26(4):367-379

• Mittal, R. K., Rochester, D. F., & McCallum, R. W. (1988). Electrical and mechanical activity in the human lower esophageal sphincter during diaphragmatic contraction. Journal of Clinical Investigation, 81(4), 1182–1189.

• Halland, M., Pandolfino, J. E., & Kahrilas, P. J. (2021). Diaphragmatic breathing reduces postprandial reflux in patients with GERD. American Journal of Gastroenterology.

• Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. New England Journal of Medicine. 1999;340(24):1888–1899. DOI: 10.1056/NEJM199906173402407

• de Groen PC, Lubbe DF, Hirsch LJ, et al. Esophagitis associated with the use of alendronate. New England Journal of Medicine. 1996;335(14):1016–1021. DOI: 10.1056/NEJM199610033351403

• Kikendall JW., Pill esophagitis. Journal of Clinical Gastroenterology. 1999;28(4): 298–305.​

• Correlation Between Gastroesophageal Reflux Disease and Small Intestinal Bacterial Overgrowth: Analysis of Intestinal Microbiome and Metabolic Characteristics, NIH 2025 Jan 4:18:33-51. doi: 10.2147/JIR.S487185. eCollection 2025.

• Systematic review: Rebound acid hypersecretion after therapy with proton pump inhibitors, NIH, 2007 Jan 1;25(1):39-46. doi: 10.1111/j.1365-2036.2006.03171.x

• Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis, Expert Rev Gastroenterol Hepatol, 2023 May;17(5):479-487.

• Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405(6785):458–462. DOI: 10.1038/35013070

• Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. Journal of Clinical Investigation. 2007;117(2):289–296. DOI: 10.1172/JCI30555

• Bonaz B, Sinniger V, Pellissier S. Anti-inflammatory effects of vagal nerve stimulation with a special attention to intestinal barrier dysfunction. Neurogastroenterology & Motility. 2022;34(10):e14456. DOI: 10.1111/nmo.14456

• Bonaz B, Bazin T, Pellissier S. The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis. Frontiers in Neuroscience. 2018;12:49. DOI: 10.3389/fnins.2018.00049

• Moazzez R., Bartlett D., Anggiansah A.: „The effect of chewing sugar-free gum on gastro-oesophageal reflux." Journal of Dental Research, 2005, 84(11), S. 1062–1065

• Ghoshal, U. C., Shukla, R., Ghoshal, U., Gwee, K. A., Ng, S. C., & Quigley, E. M. M. (2017). The gut microbiota and irritable bowel syndrome: friend or foe? International Journal of Inflammation, 2017, Article ID 1510852.

• Feldman, M., & Barnett, C. (1991). Relationships between gastric emptying and gastric secretion. Gastroenterology, 101(2), 418–423.

• Pub Med: Walking and chewing reduce postprandial acid reflux, B Avidan, A Sonnenberg, T G Schnell, S J Sontag, 2001 Feb;15(2):151-5. doi: 10.1046/j.1365-2036.2001.00902.x.

• Association of gastroesophageal reflux disease with small intestinal bacterial overgrowth: a case-control study, 
  Clinical Medical School, Xuzhou Medical University, Xuzhou 221009, China, BMC Gastroenterology 2025

• European Review for Medical and Pharmacological Sciences 2013: Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux -> https://www.europeanreview.org/wp/wp-content/uploads/3272-3278.pdf

• ​PMC PubMed Central: GERD Symptoms in the General Population: Prevalence and Severity Versus Care-Seeking Patients: Dig Dis Sci. 2014 May 9;59(10):2488–2496. 

• PMC PublicMed Central:  2022 Sep 2;101(35): e30487. Evidence-based treatment recommendations for gastroesophageal reflux disease during pregnancy.

• PMC PubMed Central: Gastroenterol Clin North Am. 2013 Dec 27;43(1):161–173. doi: Obesity & GERD.

• Cureus Journal of Medical Science: The Effects of Proton Pump Inhibitors in Acid Hypersecretion-Induced Vitamin B12 Deficiency: A Systematic Review (2022)

• Behrens M., Meyerhof W. – „Gustatory and extragustatory functions of mammalian taste receptors." Physiology & Behavior, 2011 

• Newsholme P., Procopio J., Lima M. M. R., Pithon-Curi T. C., Curi R. – „Glutamine and glutamate as vital metabolites." Brazilian Journal of Medical and Biological Research, Feb 2003.

• de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiological Reviews. 2015;95(1):1–46. DOI: 10.1152/physrev.00012.2014

• Touyz RM. Magnesium in clinical medicine. Frontiers in Bioscience. 2004;9:1278–1293. DOI: 10.2741/1316

• Hille B. Ion Channels of Excitable Membranes. 3rd edition. Sunderland, MA: Sinauer Associates; 2001. ISBN: 978-0878933211

• Schmidt RF, Lang F, Heckmann M. Physiologie des Menschen. 32. Auflage. Berlin: Springer; 2017. ISBN: 978-3662287736

• Webb RC. Smooth muscle contraction and relaxation. Advances in Physiology Education. 2003;27(1-4):201–206. DOI: 10.1152/advan.00025.2003

• Sanders KM, Koh SD, Ro S, Ward SM. Regulation of gastrointestinal motility—insights from smooth muscle biology. Nature Reviews Gastroenterology & Hepatology. 2012;9(11):633–645. DOI: 10.1038/nrgastro.2012.168

• Journal of Medicinal Food, 10(1), 194–196. DOI: Effectiveness of dried Carica papaya seeds against human intestinal parasitosis: a pilot study, Okeniyi, J. A., Ogunlesi, T. A., Oyelami, O. A., & Adeyemi, L. A. (2007). 10.1089/jmf.2005.065 PMID: 17472487

• EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of health claims related to vitamin B1 (Thiamin). EFSA Journal. 2009;7(9):1222.

• EFSA NDA Panel: Scientific Opinions zu Vitamin B1, B2, B3, B5, B6, B7 und B12. EFSA Journal, 2009–2010. (efsa.europa.eu)

• Depeint F et al. Mitochondrial function and toxicity: role of the B vitamin family. Chem Biol Interact. 2006;163(1-2):94–112.

• EFSA NDA Panel. Scientific Opinion on health claims related to vitamin C. EFSA Journal. 2009;7(9):1226 und EFSA Journal. 2010;8(10):1815. (efsa.europa.eu)

• Hansen SN et al. Does vitamin C deficiency affect cognitive development and function? Nutrients. 2014;6(9):3818–3846.

• DePhillipo NN et al. Efficacy of Vitamin C Supplementation on Collagen Synthesis. Orthop J Sports Med. 2018;6(10).

• Löffler G., Petrides P. E., Heinrich P. C. – Biochemie und Pathobiochemie. Springer Verlag (aktuelle Auflage). Kapitel über Aminosäurestoffwechsel / Glutaminmetabolismus.

• MDPI - Gastrointestianal Disorders:  Updates in Gastroesophageal Reflux Disease Management: From Proton Pump Inhibitors to Dietary and Lifestyle Modifications, Gastrointest. Disord. 2025, Published: 30 April 2025

• Frontiers in Nutrition (Aug. 2025): Therapeutic effects of olive leaf tea (Olea europaea L.) on gastrointestinal symptoms and body composition in adults with small intestinal bacterial overgrowth 

• Die Darm-Hirn Connection, Prof. Dr. Gregor Hasler, 3. Auflage, Klett-Cotta Verlag, ISBN.Nr. 978-3-608-98384-5

• Darm mit Charme, Giulia Enders, 2. Auflage, Ullstein Taschenbuchverlag, ISBN-Nr. 978-3-548-37589-2

• Der Selbstheilungsnerv, So bringt der Vagus-Nerv Psyche und Körper ins Gleichgewicht, Stanley Rosenberg,
  13. Auflage 2022, VAK Verlags GmbH, ISBN 978-1-62317-024-0​

• UpToDate; Wolters Kluwer; Medical management of gastroesophageal reflux disease in adults

• Journal of Medicinal Food: Effectiveness of Dried Carica papaya Seeds Against Human Intestinal Parasitosis: A Pilot Study, https://journals.sagepub.com/doi/abs/10.1089/jmf.2005.065

• Hausarzt.digital: "Alternativen bei Reflux"

• Spektrum der Wissenschaft KOMPAKT 45.20; ATMEN

• natur & heilen, Zeitschrift für gesundes Leben, Die Sympathikus-Therapie, November 2022

• Das grosse Buch der Heilpflanzen, Pahlow, GU Verlag, ISBN 978-3-833-7926-5

• Das grosse Lexikon der Heilpflanzen, Andrew Chevalier, DK Verlag, ISBN 978-3-8310-3232-7